The Misty River is a campaign world set far into the future of our own human world - far enough into the future that other sentient, humanoid species have evolved or developed by other methods. The Misty River region itself corresponds to the present-day Mississippi River watershed.

The campaign setting occurs an arbitrary period of time in our own future - while the exact time elapsed is unknown and does not matter, it can be assumed to be anywhere from 50,000 to 250,000 years in our future. At